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A schematic diagram illustrating the regulation of the Zn2+-responsive TCS CzcS/CzcR on swimming motility in P. aeruginosa. The CzcR protein is upregulated and phosphorylated to activate the expression of genes involved in flagellar biosynthesis directly (solid orange arrow) by interacting with their promoters or indirectly (dashed orange arrow) through other unknown regulators, which is essential for flagellar biosynthesis and swimming motility of P. aeruginosa during Zn2+ stress.
