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Identification of an inhibitor of P. falciparum lipid synthesis from the Malaria Box. (A) Screen of 20 pools representing 71 Malaria Box compounds for inhibition of parasite neutral lipid synthesis. C, no inhibitor control; A, ATFK (10 μM) positive control for inhibition. o, origin; FA, C4,C9-FA. The red asterisk indicates inhibition by pool 11. (B) Identification of the active compound in pool 11. a, b, c, d represent the four compounds in the pool; compound c is MMV665915.
