TABLE 3.
Category | Species | Agent | MIC (μg/mL) | MBCc (μg/mL) | MBC/MIC ratiod |
---|---|---|---|---|---|
SGM | M. kansassi | BDQa | 0.0078 | 0.25 | 32 |
WX-081b | 0.01563 | 1 | 64 | ||
M. intracellulare | BDQ | 0.0078 | 0.5 | 64 | |
WX-081 | 0.01563 | 2 | 128 | ||
M. avium | BDQ | 0.0078 | 0.5 | 64 | |
WX-081 | 0.01563 | 1 | 64 | ||
RGM | M. fortuitum | BDQ | 0.0078 | 1 | 128 |
WX-081 | 0.0078 | 1 | 128 | ||
M. abscessus | BDQ | 0.125 | 4 | 32 | |
WX-081 | 0.25 | 16 | 64 |
BDQ, bedaquiline.
WX-081, sudapyridine.
MBC, minimum bactericidal concentration.
The effect was considered bacteriostatic if the MBC/MIC ratio was higher than 4; otherwise, it was considered bactericidal.