TABLE 2.
Distributions of MICs and MIC50 and MIC90 values of anidulafungin against worldwide intrapulmonary isolates of Aspergillus fumigatus, Aspergillus nidulans, Aspergillus terreus, Aspergillus niger, and Aspergillus flavus species complex cultured from 2017 through 2020 in the Antimicrobial Testing Leadership and Surveillance projecta
| Aspergillus spp. (no. of isolates) | No. of isolates (cumulative %) according to MIC (μg/mL) |
MIC50/MIC90 (μg/mL) | ||||||
|---|---|---|---|---|---|---|---|---|
| 0.002 | 0.004 | 0.008 | 0.016 | 0.03 | 0.06 | 0.12 | ||
| Aspergillus fumigatus (660) | 26 (3.9) | 91 (17.7) | 167 (43) | 241 (79.5) | 110 (96.2) | 25 (100) | 0016/0.03 | |
| Aspergillus fumigatus if MICs of VRC >2 μg/mL (22) | 2 (9.1) | 3 (22.7) | 8 (59.1) | 6 (86.4) | 2 (95.5) | 1 (100) | 0.008/0.03 | |
| Aspergillus nidulans spp. complex (26) | 2 (7.7) | 4 (23.1) | 5 (42.3) | 11 (84.6) | 3 (96.2) | 0 (96.2) | 1 (100) | 0.016/0.03 |
| Aspergillus terreus spp. complex (40) | 3 (7.5) | 4 (17.5) | 10 (42.5) | 15 (80) | 7 (97.5) | 1 (100) | 0.016/0.03 | |
| Aspergillus niger spp. complex (107) | 21 (19.6) | 40 (57) | 32 (86.9) | 11 (97.2) | 3 (100) | 0.004/0.016 | ||
| Aspergillus flavus spp. complex (96) | 12 (12.5) | 34 (47.9) | 30 (79.2) | 18 (97.9) | 2 (100) | 0.008/0.016 | ||
a
Bold values in parentheses indicate the numerals of cumulative percentage above 90% of isolates for given subsets.