Fig. 8. (a) Schematic illustration of the mechanism of PALNs formation. (b) Graphical illustration of entrapment efficiency of 17 tested drug formulations (reprinted with permission from ref. 69 Copyrights 2020 AAPS). (c) In vitro release profiles of PLGA-NPs in STF with pH of 7.4. (d) The concentration of ACV in aqueous humor after topical ocular administration of formulation “F5” and ACV-AqS in eyes of rabbits (reprinted with permission from ref. 81 Copyrights 2018 Elsevier).