TABLE 2.
Comparison of in vitro activities of eight antifungal agents (μg/mL) tested against Candida species by CLSI method (<100 isolates)
| Species | Antifungals | Range (mode) | MIC50 | MIC90 | MICGM |
|---|---|---|---|---|---|
| Candida parapsilosis (60) | Amphotericin B | 0.016–1 (0.25) | 0.25 | 0.5 | 0.16 |
| Caspofungin | 0.016–2 (0.016) | 0.25 | 1 | 0.32 | |
| Voriconazole | 0.016–0.5 (0.125) | 0.032 | 0.064 | 0.05 | |
| Fluconazole | 0.064–32 (2) | 1 | 4 | 1 | |
| Itraconazole | 0.016–4 (0.125) | 0.064 | 0.25 | 0.08 | |
| Posaconazole | 0.016–2 (0.125) | 0.125 | 0.5 | 0.11 | |
| Luliconazole | 0.008–8 (1) | 1 | 2 | 0.8 | |
| Isavuconazole | 0.008–2 (0.125) | 0.032 | 1 | 0.06 | |
| Debaryomyces hansenii (31) | Amphotericin B | 0.016–0.5 (0.25) | 0.25 | 0.5 | 0.17 |
| Caspofungin | 0.016–4 (4) | 0.5 | 4 | 0.4 | |
| Voriconazole | 0.016–8 (0.016) | 0.5 | 8 | 0.36 | |
| Fluconazole | 0.125–32 (32) | 16 | 32 | 4.64 | |
| Itraconazole | 0.016–8 (8) | 1 | 8 | 0.68 | |
| Posaconazole | 0.016–4 (0.016) | 0.5 | 4 | 0.3 | |
| luliconazole | 0.008–4 (1) | 1 | 4 | 0.31 | |
| isavuconazole | 0.008–2 (0.008) | 0.125 | 0.5 | 0.08 | |
| Candida tropicalis (23) | Amphotericin B | 0.064–1 (0.25) | 0.25 | 0.5 | 0.2 |
| Caspofungin | 0.016–0.125 (0.016) | 0.016 | 0.064 | 0.02 | |
| Voriconazole | 0.016–2 (0.125) | 0.064 | 0.25 | 0.05 | |
| Fluconazole | 0.250–16 (2) | 0.25 | 8 | 1.53 | |
| Itraconazole | 0.016–4 (0.125) | 0.064 | 0.25 | 0.18 | |
| Posaconazole | 0.016–2 (0.125) | 0.25 | 2 | 0.34 | |
| Luliconazole | 0.008–4 (1) | 0.5 | 2 | 0.45 | |
| Isavuconazole | 0.008–2 (0.125) | 0.032 | 1 | 0.05 | |
| Pichia kudriavzevii (17) | Amphotericin B | 0.016–1 (0.25) | 0.125 | 1 | 0.15 |
| Caspofungin | 0.016–2 (0.016) | 0.125 | 2 | 0.15 | |
| Voriconazole | 0.016–0.25 (0.125) | 0.125 | 0.25 | 0.08 | |
| Fluconazole | 0.250–64 (2) | 8 | 32 | 6.34 | |
| Itraconazole | 0.032–2 (0.125) | 0.125 | 2 | 0.23 | |
| Posaconazole | 0.064–1 (0.125) | 0.125 | 1 | 0.21 | |
| Luliconazole | 0.008–2 (1) | 0.5 | 1 | 0.32 | |
| Isavuconazole | 0.008–0.5 (0.125) | 0.125 | 0.25 | 0.06 | |
| Candida orthopsilosis (13) | Amphotericin B | 0.016–0.125 (0.25) | 0.064 | 0.064 | 0.04 |
| Caspofungin | 0.064–0.25 (0.016) | 0.125 | 0.25 | 0.15 | |
| Voriconazole | 0.016–0.064 (0.125) | 0.032 | 0.064 | 0.03 | |
| Fluconazole | 1–2 (2) | 2 | 2 | 1.6 | |
| Itraconazole | 0.125–1 (0.125) | 0.125 | 0.5 | 0.22 | |
| Posaconazole | 0.032–0.5 (0.125) | 0.125 | 0.25 | 0.15 | |
| Luliconazole | 0.064–2 (1) | 0.25 | 2 | 0.28 | |
| Isavuconazole | 0.008–0.032 (0.125) | 0.016 | 0.032 | 0.1 | |
| Meyerozyma guilliermondii (12) | Amphotericin B | 0.016–0.5 (0.125) | 0.125 | 0.5 | 0.09 |
| Caspofungin | 0.016–1 (0.016) | 0.25 | 4 | 0.17 | |
| Voriconazole | 0.016–0.125 (0.016) | 0.032 | 0.125 | 0.04 | |
| Fluconazole | 0.250–16 (0.25) | 1 | 16 | 1.41 | |
| Itraconazole | 0.016–8 (0.5) | 0.25 | 0.5 | 0.20 | |
| Posaconazole | 0.016–8 (0.5) | 0.5 | 8 | 0.38 | |
| Luliconazole | 0.008–1 (0.032) | 0.032 | 0.25 | 0.05 | |
| Isavuconazole | 0.008–0.125 (0.064) | 0.064 | 0.125 | 0.04 | |
| Kluyveromyces marxianus (11) | Amphotericin B | 0.016–1 (0.5) | 0.25 | 0.5 | 0.2 |
| Caspofungin | 0.016–0.125 (0.016) | 0.016 | 0.125 | 0.03 | |
| Voriconazole | 0.016–0.125 (0.016) | 0.016 | 0.125 | 0.04 | |
| Fluconazole | 0.125–0.5 (0.5) | 0.5 | 0.5 | 0.42 | |
| Itraconazole | 0.032–0.25 (0.125) | 0.125 | 0.25 | 0.12 | |
| Posaconazole | 0.016–0.032 (0.016) | 0.016 | 0.032 | 0.02 | |
| Luliconazole | 0.008–0.125 (0.008) | 0.008 | 0.125 | 0.02 | |
| Isavuconazole | 0.008–0.016 (0.008) | 0.008 | 0.016 | 0.01 |