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Schematic representation of the proposed role of ASFV MGF110-7L in subversion of the host protein translation. ASFV-encoded MGF110-7L could trigger ER stress and activate the PERK and IRE1α-XBP1 branches of the UPR. The ER stress and UPR induction promotes the phosphorylation of eIF2α by activating the kinases PERK and PKR, resulting in host translation arrest and SG formation.
