FIG 7.

The association heatmap of microbial species, serum metabolites, and clinical parameters. The signs of change trend for each paired samples in cohort were calculated, and then normalized mutual information score was used to evaluate the association of change trends. Normalized mutual information score ranges from 0 to 1, indicating that the association between the 2 trends ranges from weak to strong. The sign of score was evaluated by the direction consistency of 2 trends. Permutation test (1000 permutations) was performed to determine P-value of correlation. * and ⁺ suggest the significance, ⁺, P < 0.05; *, P < 0.01.