FIG 8.

The cross talk between host and gut microbiota in SCAD patients. The increased acylcarnitine (Acs) levels suggests impairment of the mitochondrial fatty acid β-oxidation in SCAD patients, and the reduced unsaturated fatty acid levels would further reduce cardiac fatty acid oxidation and greatly affects cardiac energy and function. More importantly, the reduced unsaturated fatty acid level might be caused by Ralstonia pickettii, which holds a core position in the functional changes of intestinal microbiota. Further, R. pickettii may affect the heart health of host by changing the amino acid biosynthesis, B vitamin biosynthesis, LPS biosynthesis, and acetic acid production of intestinal flora.