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. 2022 Nov 15;10(6):e01970-22. doi: 10.1128/spectrum.01970-22

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Copyright © 2022 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — (A) Structures of representative redox cycling antimycobacterial agents. The systemic nomenclature of SA23 is 3-butyl-2-methyl-1-octyl-4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide. Minimum inhibitory concentrations (MIC₉₀) on M. tb H37Rv or M. bovis BCG are (i) Clofazimine MIC_MtbH37Rv, 0.25 μM (28); MIC_BCG, 0.4 μM (11); (ii) QQ8c MIC_MtbH37Rv, 8.1 μM; MIC_BCG, 8.1 μM (10); (iii) ATD-3169 MIC_MtbH37Rv, 3.1 μM (12); (iv) SA23 MIC_MtbH37Rv, 1.5 μM; MIC_BCG, 0.26 μM (11). (B) Structures of SA23 analogues: SA72 MIC_MtbH37Rv, 1.2 μM; MIC_BCG, 0.27 μM; SA33 MIC_BCG, 15 μM; SA34 MIC_BCG, 11 μM (11).