TABLE 2.
Concentrations of antifungal agents in bone and synoviuma
| Antifungal agent | Concn(s) in bone and bone marrow | Concn in synovium | Concn in nucleus pulposus |
|---|---|---|---|
| Amphotericin B deoxycholate | Bone marrow, 2.7 μg/g (dosed at 0.6 mg/kg), 8.0 ± 1.7 μg/g | 0.29 μg/mL; 40% of plasma concn | Not detected |
| ABLC | Bone marrow, 35.4 ± 12.7 μg/g | No data available | Not detected |
| ABCD | Bone marrow, 7.5 μg/g (dosed at 0.6 mg/kg), 9.9 μg/g (dosed at 1.2 mg/kg), 3.3 μg/g (dosed at 2.5 mg/kg), 96 μg/g (dosed at 5.0 mg/kg) | No data available | |
| Liposomal amphotericin B | Bone marrow, 39.5 ± 4.7 μg/g (dosed at 5.0 mg/kg) | 0.79 μg/mL; 140% of plasma concn | |
| Fluconazole | Bone, 33% of serum concn | 14.19 ± 5.07 μg/mL (horse) | 10.86 ± 21.42 μg/g; median value, 3.7 μg/g |
| Itraconazole | 470% of plasma concn | ||
| Voriconazole | Medullary bone, 20.3 μg/g; cortical bone, 1.9 μg/g | 30% of plasma concn (human); 60% of plasma concn (horse) | |
| Posaconazole | No data available | No data available | |
| Isavuconazole | Bone, 0.048–0.070 μg (eq/g); bone marrow, 0.054–0.822 μg (eq/g) ([14C]isavuconazonium sulfate orally at 5 mg/kg as a single dose to rats) | No data available | |
| Caspofungin | No data available | No data available | |
| Micafungin | No data available | No data available | |
| Anidulafungin | 4,830 ng/mL (male rats at postnatal day 4 dosed at 10 mg/kg once), 9,600 ng/mL (female rates at postnatal day 4 dosed at 10 mg/kg once), 7,220 ng/mL (all rats at postnatal day 8 dosed at 10 mg/kg once), 6,050 ng/mL (male rats at postnatal day 4 dosed at 10 mg/kg once, 7,800 ng/mL (male rates at postnatal day 8 after multiple doses at 10 mg/kg) | No data available | |
| 5-Fluorocytosine | 30% of max serum concn, 15% at 2 h postinjection, 6% at 4 h postinjection | 41% of max serum concn |