TABLE 6.

Antifungal compounds available for the treatment of paracoccidioidomycosis^d

Antifungal compound	Formulation	Total daily dose	Interval between doses	Route of administration	Method of drug intake (empty or full stomach)
Azole compounds
Ketoconazole	Tablet	400 mg	q24h	Oral	Empty
	Solutionc	5–8 mg/kg	q24h	Oral	Empty
Itraconazole	Capsule	200 mg	q24h	Oral	Full
	Capsule	200 mg	q12h	Oral	Full
Fluconazole	Tablet	400 mg	q12h	Oral	Without regard to meals
	Glass bottle	400 mg	q12h	Intravenous
Voriconazolea	Tablet	400 mg	q12h	Oral	1 h before or 1 h after a meal
	Glass bottle	400 mg	q12h	Intravenous
Amphotericin B
AmB-db	Glass bottle	50 mg	q48h	Intravenous
ABLC	Glass bottle	3.5 mg/kg	q24h	Intravenous
TMP-SMX combination	Tablet	480–2,400 mg	q12h	Oral	Without regard to meals
	Suspensionc	16–20 mg/kg TMP	q12h	Oral	Without regard to meals
	Glass bottle	480–2,400 mg	q12h	Intravenous

^aFour hundred milligrams twice on the first day is usually given as a loading dose.

^bAmB-d (amphotericin B deoxycholate) should be used at increasing doses up to 1.0 mg/kg of body weight, not exceeding 50 mg/dose.

^cDosage for children.

^dABLC, amphotericin B lipid complex; TMP-SMX, trimethoprim-sulfamethoxazole, also called co-trimoxazole; q24h, every 24 h.