TABLE 7.
Clearance of endogenous creatinine (mL/min) | f |
---|---|
20–24 | 0.30 |
25–29 | 0.35 |
30–35 | 0.40 |
36–40 | 0.45 |
41–46 | 0.50 |
47–52 | 0.55 |
53–57 | 0.60 |
58–63 | 0.65 |
64–68 | 0.70 |
69–74 | 0.75 |
75–79 | 0.80 |
80–85 | 0.85 |
86–90 | 0.90 |
91–96 | 0.95 |
>97 | 1.00 |
The formula for calculating the doses of amphotericin B according to the clearance of endogenous creatinine is Dc = D × f, where Dc is the corrected dose, D is the dose planned to be administered, and f is the correction factor (323).