TABLE 8.
Some drug interactions involving azole antifungal compoundsa
| Effect of interaction | Drug(s) interacting with: |
|||
|---|---|---|---|---|
| Ketoconazole | Itraconazole | Fluconazole | Voriconazole | |
| Decreased absorption of azoles | Antacids | Antiacids | ||
| H2 receptor antagonists | H2 receptor antagonists | |||
| Proton pump inhibitors | Proton pump inhibitors | |||
| Sucralfate | ||||
| Decreased plasma levels of azoles due to metabolism | Rifampicin | Rifampicin | Rifampicin | Rifampicin |
| Rifabutin | Rifabutin | Rifabutin | ||
| Phenytoin | Phenytoin | Phenytoin | ||
| Isoniazid | Isoniazid | |||
| Carbamazepine | Carbamazepine | |||
| Nevirapine | ||||
| Phenobarbital | ||||
| Increased plasma levels of the coadministered drug | Warfarin | Warfarin | Warfarin | Warfarin |
| Sulfonylureas | Sulfonylureas | Sulfonylureas | Sulfonylureas | |
| Cyclosporine | Cyclosporine | Cyclosporine | Cyclosporine | |
| Tacrolimus | Tacrolimus | Tacrolimus | Tacrolimus | |
| Phenytoin | Phenytoin | Phenytoin | Phenytoin | |
| Midazolam | Midazolam | Midazolam | Midazolam | |
| Triazolam | Triazolam | Triazolam | Triazolam | |
| Alprazolam | Alprazolam | Alprazolam | Alprazolam | |
| Corticosteroids | Felodipine | Theophylline | Statins | |
| Theophylline | Verapamil | Zidovudine | Omeprazole | |
| Ritonavir | Pimozide | Rifabutin | Vinca alkaloids | |
| Saquinavir | Statins | |||
| Ritonavir | ||||
| Saquinavir | ||||
| Indinavir | ||||
| Digoxin | ||||
a
See reference 380.