TABLE 2.
Summary of archived mutations and polymorphisms found in viral reservoirs
| Patient | Exposure to RAL | Major DRMs | Accessory DRMs | Polymorphisms |
|---|---|---|---|---|
| 1 | No | None | E157EQ | K14R, W19W*, V31I, L45LI, K46KQ, L101I, T112V, S119P, T122TI, T124A, T125A, W132W*, G134N, K136T, D167E, S195T, V201I, T206S, L234I, R269RK, S283G, D286DN |
| 2 | Yes | G140R, G163R | G4R, E11D, K14R, A21T, A23V, D41N, G47R, M50I, I72V, L101I, T112V, S119T, T124N, T125A, G134N, K136Q, R166K, D167E, V201I, R224Q, L234V, S255D, G272R, S283G, D288N | |
| 3 | No | None | L74I | S17N, R20RK, V31I, L63IV, I72V, K111R, T112V, T124A, T125A, G134N, K136T, D167E, T174TP, V201I, T206S, I220IV, L234I, R269K, R284G, D286N |
| 4 | No | None | L74I | L2LF, K14R, V31I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, R224RW, R228RK, P233PS, L234I, R269K |
| 5 | Yes | None | K14R, S24N, V31I, L101I, G134N, K136T, K173R, T174TP, V201I, T206S, T218S, L234I, S255N, D256E, S283G | |
| 6 | No | None | K14R, S17N, L28I, V31I, S39C, I72V, T112V, T124A, T125A, K136T, S153SA, L158I, T174TP, G197GV, V201I, T206S, T218I, L234I, S283SG, D288DE | |
| 7 | Yes | None | E11D, K14R, S17T, R20K, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, Q221QK, R224RW, Y227F, P233PS, L234I, L241LV, L242LV, W243WR, S283G | |
| 8 | No | None | L74I | E11D, K14R, A21T, V31I, I72V, A91G, Y99F, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T218S, R224RW, P233PS, L234I, W235WR, L241LV, L242LV, W243WR, V250VI, D256DE, D270DV |
| 9 | No | None | K14R, A23AV, V31I, S57SG, L101I, T112IV, T124A, T125A, G134N, I135V, K136T, V201I, K215KT, R224RW, P233PS, L234I, L241LV, D256DE, I268IF, S283G, R284G, D288N | |
| 10 | Yes | None | E11D, K14R, S17C, A23V, V31I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218TS, R224RW, P233PS, L234I, S255SR, I268IF, D278DE, V281VG, S283SG, D288DE | |
| 11 | No | None | L74I | L2F, S17N, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, D256E, R269K, D278N, S283G, R284RG |
| 12 | No | None | L74I | D6E, K14R, S17N, D25E, V31I, I60V, L63I, I72V, T97S, L101I, T112V, S119T, T124A, T125A, G134N, I135V, K136T, K188R, V201I, I203M, T218S, L234I, R269K, K273Q, D278A, S283G, D288N |
| 13 | Yes | None | K14R, S17SN, V31VI, I72IV, L101LI, L104LV, T112I, T124A, T125AV, G134N, I135V, K136T, V201I, T206TS, L234I, D256DE, R269RK, S283G | |
| 14 | Yes | None | K14R, S17SN, S24SN, S39SN, M50MI, L101I, L104V, T112V, I113IV, S119ST, T124DN, T125A, I135IV, K136T, V201I, T206TS, R224RW, L234I, D256DE, K264KE, S283G | |
| 15 | Yes | None | E11D, K14R, A21T, A23V, V31I, M50I, T93N, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T218S, L234I, S283G, D288N | |
| 16 | Yes | None | E10EQ, E11D, K14R, V32I, D41N, I72V, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, L234I, S283G, R284G, D286E, D288N | |
| 17 | No | None | K14R, K34R, I72IV, E85EK, L101I, T112V, I113IV, T124A, T125A, A133AT, G134N, I135V, K136T, V201I, T206S, L234I, M275V, S283G | |
| 18 | No | None | S17N, L45P, K103R, T112V, I113V, S119P, T124N, T125V, K136Q, V201I, T206TS, L234I, D256E, S283G |