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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5;21(7):1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

Fig. 6. RBN-2397 induces G1 arrest and apoptosis through AHR activity.

Fig. 6

A, Schematic of the FastFUCCI cell cycle reporter system14. Red, yellow and green fluorescent cells correspond to the cells in G1, G1/S and S/G2-M, respectively. B, Cell cycle analysis of FastFUCCI labeled NCI-H1373 treated with the indicated drugs for 48 h. C, RT-qPCR data showing the relative mRNA levels of p27/CDKN1B in parental and AHR knockout cells treated with the indicated drugs for 24 h. D, Western blots of cell lysates from parental and AHR knockout NCI-H1373 cells treated with the indicated concentrations of RBN-2397 for 48 h. E, Fraction of parental (top) and AHR knockout (bottom) NCI-H1373 cells staining positive for Annexin V treatment with the indicated drugs for 24 h. Data shown as mean values ± SD; n = 3.