TABLE 3.

Differentially expressed genes in K. pneumoniae ATCC 13883 with fluticasone treatment^a

Expression type and gene	Expression with fluticasone
	Log2FC	P
Higher expression
eptB	1.533	0.018
pstS	1.364	0.046
birA	1.284	0.027
rpsB	1.142	0.006
ydhP_2	1.136	0.035
yjdJ	1.086	0.007
nusA	0.974	0.030
glyS	0.958	0.045
ftnA_2	0.881	0.015
osmB	0.759	0.006
cspE	0.736	0.013
yjhP	0.726	0.025
purL	0.711	0.004
ftnA_1	0.657	0.020
rpsJ	0.650	0.023
csrA	0.643	0.000
ylaC	0.621	0.031
raiA	0.612	0.001
dinJ	0.603	0.030
sodB	0.588	0.043
bssS	0.558	0.039
ybiV	0.528	0.046
dps	0.451	0.000
yobA_2	0.439	0.028
gntK	0.429	0.042
ymiA	0.426	0.001
ompX	0.424	0.023
uspG_2	0.421	0.014
ompC	0.407	0.003
rplM	0.403	0.025
speE	0.398	0.012
bglA_2	0.371	0.033
frr	0.358	0.032
ppiB	0.355	0.037
hldD	0.347	0.017
yqjC	0.341	0.003
hns_2	0.338	0.023
ynfD	0.331	0.003
spy	0.330	0.009
fnr	0.320	0.043
gapA	0.303	0.003
ompA	0.302	0.005
rplJ	0.290	0.044
ppa_2	0.282	0.035
lldR_2	0.282	0.047
arcA	0.259	0.008
nlpI	0.254	0.020
tolC	0.251	0.029
cyoA	0.250	0.044
yccA	0.249	0.045
grxD	0.243	0.034
ahpC_2	0.242	0.034
uspA	0.241	0.044
repB	0.238	0.044
folE	0.232	0.030
eno	0.224	0.043
rpoH	0.223	0.041
crp	0.191	0.049
Lower expression
rpmE2	–3.267	0.029
rlmM	–1.664	0.037
thlA_2	–1.599	0.046
galA	–1.597	0.021
zinT	–1.539	0.049
fiu	–1.337	0.026
entB	–1.180	0.021
entA	–1.048	0.034
mtgA	–0.940	0.009
entS	–0.931	0.018
hscB	–0.925	0.028
wecB	–0.893	0.045
sutR_2	–0.772	0.022
bcsB_1	–0.670	0.027
cbiE	–0.629	0.007
fieF_2	–0.603	0.018
dipZ	–0.537	0.049
abgB	–0.525	0.028
mdtD_2	–0.514	0.045
hemH	–0.489	0.037
murG	–0.360	0.040
dxs_3	–0.333	0.048
lsrG	–0.320	0.031
chaC_2	–0.295	0.018
gloC	–0.290	0.045

^aRNA-seq was performed on biological triplicates of fluticasone-exposed versus vehicle-only exposed bacteria after 6 h of culture. The log₂ fold change (Log2FC) between groups was determined using DESeq2. Transcripts reaching a threshold of P < 0.05 (unadjusted) from this exploratory analysis are shown.