TABLE 3.
Effectiveness of NOS in combination with antituberculosis drugs against M. tuberculosis H37Rva
| Antibiotic combination | MIC (ug/ml) |
FICI | Outcome | |
|---|---|---|---|---|
| Antibiotics alone | Combinations | |||
| NOS + INH | 0.125/0.05 | 0.0625/0.0125 | 0.75 | Partial synergy |
| NOS + RIF | 0.125/0.032 | 0.125/0.016 | 1.5 | Indifference |
| NOS + MFX | 0.125/0.0625 | 0.125/0.0625 | 2 | Indifference |
| NOS + LZD | 0.125/0.25 | 0.0625/0.125 | 1 | Additive |
| NOS + CFZ | 0.125/0.062 | 0.125/0.125 | 3 | Indifference |
| NOS + BDQ | 0.125/0.031 | 0.0625/0.016 | 1 | Additive |
a
BDQ, bedaquiline; CFZ, clofazimine; FICI, fractional inhibitory concentration index; INH, isoniazid; LZD, linezolid; MFX, moxifloxacin; RIF, rifampicin.