FIG 6.

Oral gavage of B. animalis alleviates DSS-induced acute colitis in mice. (A) Experimental scheme for DSS-induced colitis and B. animalis treatment (n = 8). (B) Body weight was recorded daily in the final week of DSS treatment for three groups of mice. The colon was collected from each mouse at the end of the experiment. (C to F) Representative images of the colon (C), the colon length (D), and H&E staining (magnification, ×50) and TEM image of the colon (E) and colonic histology score (F) are shown. (G and H) The mRNA gene expression levels of three inflammatory cytokines (G) and two BA receptors (H) in the colon were also measured by RT-qPCR. Data are presented as means ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; #, P < 0.05; compared with the DSS plus B. animalis group.