TABLE 2.
Cross-resistance of profile of NSC19723-resistant mutants
| Treatment | MIC (μM)a |
|||
|---|---|---|---|---|
| M. bovis BCG Pasteur-WT | M. bovis BCG Pasteur-NSC19723r HadCT123A | M. bovis BCG-pVV16 | M. bovis BCG-pVV16-hadABC | |
| NSC19723 | 0.39–0.78 | >50 | 0.78 | 25–50 |
| Thiacetazone | 3.12–6.25 | >50 | 3.12–6.25 | >50 |
| Isoniazid | 0.39 | 0.39 | 0.39 | 0.39 |
| Rifampicin | 0.0039–0.0078 | 0.0078 | ND | ND |
| Levofloxacin | 0.39 | 0.39 | ND | ND |
| Ethionamide | 12.5–25 | 12.5 | ND | ND |
a
The data shown is representative of three experiments performed in duplicates. WT, wild type; NSC19723r, NSC19723 resistant; ND, not done.