TABLE 2.
Sensitivity, specificity, accuracy, PPV, and NPV of Xpert Carba-R pooling strategy for individual CRG in comparison with culture and sequencinga
| Culture and sequencing (reference method) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Xpert Carba-R | blaNDM+ | blaNDM− | blaKPC+ | blaKPC− | blaVIM+ | blaVIM− | blaIMP+ | blaIMP− | blaOXA+ | blaOXA− |
| No. of positive | 23 | 2 | 4 | 1 | 1 | 0 | 6 | 1 | 0 | 0 |
| No. of negative | 0 | 389 | 0 | 409 | 0 | 413 | 0 | 407 | 0 | 414 |
| Sensitivity (95% CI) | 100% (82.2% to 100%) | 100% (39.6% to 100%) | 100% (5.5% to 100%) | 100% (51.7% to 100%) | NA | |||||
| Specificity (95% CI) | 99.5% (98.0% to 99.9%) | 99.8% (98.4% to 99.9%) | 100% (98.9% to 100%) | 99.8% (98.4% to 99.8%) | 100% (98.9% to 100%) | |||||
| Accuracy (95% CI) | 99.5% (98.0% to 99.9%) | 99.8% (98.5% to 99.9%) | 100% (98.9% to 100%) | 99.8% (98.5% to 99.9%) | 100% (98.9% to 100%) | |||||
| PPV (95% CI) | 92.0% (72.5% to 98.6%) | 80.0% (29.9% to 99.0%) | 100% (5.5% to 100%) | 85.7% (42.0% to 99.2%) | NA | |||||
| NPV (95% CI) | 100% (98.8% to 100%) | 100% (988% to 100%) | 100% (98.9% to 100%) | 100% (98.8% to 100%) | 100% (98.9% to 100%) | |||||
a
NA, not applicable; PPV, positive predictive value; NPV, negative predictive value.