TABLE 2.
Activity of 11726172 against a panel of M. tuberculosis strains
| Straina | MIC (μg/mL) |
Reference | |
|---|---|---|---|
| 11726172 | INH | ||
| H37Rv | 0.25 | 0.05 | |
| IC1 (resistant to STR, INH, RIF, EMB) | 0.25 | >2 | 22 |
| IC2 (resistant to STR, INH, RIF, EMB, PYR, ETH, CM) | 0.25 | >2 | 22 |
| 53.3 (Rv2466c, W28S) | 0.25 | 0.05 | 16 |
| 53.8 (Rv0579, L240V; Rv0158, V48A; esxD, M41R) | 0.25 | 0.05 | 23 |
| NTB1 (DprE1, G387S) | 0.25 | 0.05 | 24 |
| DR1 (Mmpl3, V681I) | 0.25 | 0.05 | 25 |
| Ty1 (Rv3405c, c190t) | 0.25 | 0.05 | 26 |
| 88.1 (CoaA, Q207R) | 0.25 | 0.05 | 27 |
| 88.7 (PyrG, V186G) | 0.25 | 0.05 | 20 |
| 81.10 (EthA, D1109-37) | 0.25 | 0.05 | 20 |
a
STR, streptomycin; INH, isoniazid; RIF, rifampin; EMB, ethambutol; PYR, pyrazinamide; ETH, ethionamide; CM, capreomycin.