TABLE 3.

Adjusted odds ratios showing the association between the NAR of the microorganisms above the cutoff and women with cervicitis and vaginitis

Variable	Multivariable analysis based on NAR above the cutoffa
	Cervicitis		Vaginitis
	aORb (95% CI)	P c	aORb (95% CI)	P c
Age (yrs)
16–25	Reference		Reference
26–35	0.20 (0.09–0.43)	<0.0001	0.32 (0.14–0.71)	0.005
36–45	0.21 (0.09–0.47)	<0.0001	0.31 (0.14–0.71)	0.005
46–55	0.14 (0.06–0.35)	<0.0001	0.20 (0.08–0.49)	<0.0001
≥56	0.06 (0.01–0.32)	0.001	0.12 (0.03–0.51)	0.004
Microorganisms
Lactobacillus spp.	0.36 (0.23–0.58)	<0.0001	0.44 (0.29–0.65)	<0.0001
T. vaginalis	3.25 (0.50–21.16)	0.217	5.74 (0.96–34.24)	0.055
M. genitalium	8.42 (1.53–46.45)	0.015	1.79 (0.21–15.48)	0.597
U. urealyticum	2.90 (1.05–8.00)	0.040	2.91 (1.10–7.70)	0.032
T. pallidum			43.23 (5.33–350.67)	<0.0001
C. trachomatis	8.74 (1.29–59.11)	0.026	4.42 (2.49–7.83)	<0.0001
K. granulomatis	1.90 (0.50–7.28)	0.347	4.65 (1.37–15.82)	0.014
M. hominis	6.29 (1.82–21.72)	0.004	10.40 (3.37–32.09)	<0.0001
U. parvum	2.45 (1.47–34.07)	0.001	1.44 (0.96–2.15)	0.077
HCMV	1.03 (0.58–1.82)	0.920	1.55 (0.97–2.47)	0.069
HHV-8	1.90 (0.81–4.47)	0.139	2.53 (1.32–4.83)	0.005
HSV-1	2.30 (0.44–12.13)	0.326	0.43 (0.05–3.46)	0.430
HSV-2			0.13 (0.01–3.63)	0.232

^aCutoff values were set according to the Youden index, calculated using MedCalc.

^bAdjustment was made in a multivariable model stratified by cohort for age (five categories).

^cBold indicates significance (P < 0.05).