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. 2022 Nov 1;10(6):e02524-22. doi: 10.1128/spectrum.02524-22

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Copyright © 2022 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 8 — Combined use of C. butyricum and B. pseudolongum effectively improves cardiac fibrosis. (A) Clade map of LEfSe analysis of mouse fecal microbes in each group. (B) Whole hearts for each group (n = 7). (C) Heart mass-to-body weight ratio of mice in each group. Representative images are shown. (D) Ejection fraction and left ventricular weight obtained by cardiac ultrasound in each group of mice. (E) qPCR analysis of Col1 and TGF-β expression in the heart tissue of mice in each group. The levels of Col1 and TGF-β in tissues from the sham group were assigned a value of 1.0. Different mRNA expression levels among the TAC, C.b+TAC, Bif+TAC, C.b+Bif+TAC, and sham groups were compared by one-way ANOVA. *, P < 0.05. (F) Masson staining and COL1A1 immunohistochemistry results of mouse hearts of mice subjected to oral gavage with C. butyricum (C.b+TAC), B. pseudolongum (Bif+TAC), or C. butyricum and B. pseudolongum (C.b+Bif+TAC) before TAC surgery (TAC) or sham operation (Sham). Magnification, ×200. Representative images are shown.