TABLE 2.
Subinhibitory concentrations of antibiotics alter ST258 survival in NHS
| Antibiotic | Change in survival of isolatea: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 34422 | 26598 | 30678 | 34576 | 34446 | 34473 | 34505 | 27386 | 27329 | 35106 | |
| Ceftazidime | ||||||||||
| Ciprofloxacin | ||||||||||
| Colistin | − | + | − | − | − | |||||
| Doxycycline | + | + | + | |||||||
| Erythromycin | + | − | ||||||||
| Linezolid | ||||||||||
| Meropenem | ||||||||||
| Mupirocin | + | + | + | + | + | + | + | |||
| Rifampin | − | + | + | |||||||
| Gentamicin | + | |||||||||
| Tigecycline | + | + | ||||||||
| Vancomycin | ||||||||||
ST258 clinical isolates were exposed to subinhibitory concentrations of the indicated antibiotics and then incubated in 90% NHS for 30 min as described in Materials and Methods. +, survival increased significantly compared to untreated control; −, survival decreased significantly compared to untreated control. Unmarked table cells indicate no significant change in survival compared to bacteria not pretreated with antibiotics (untreated control).