TABLE 2.
MICs and MBCs of MMV688845 and rifabutin against M. abscessus subsp. abscessus ATCC 19977
| Growth condition | MIC90 (μM) of: |
MBC90 (μM) of: |
||
|---|---|---|---|---|
| RFB | MMV688845 | RFB | MMV688845 | |
| 7H9 + ADS | 1.2a | 7.5a | 2.4 (2 × MIC)b | 15 (2 × MIC)b |
| Macrophage infection model | 5.5c | 15.9c | NDd | 16 (1 × MIC)e |
a
Determined in 7H9 via OD600 measurement and evaluated via method B.
b
Determined in duplicate via method B.
c
Determined by fluorescence measurement.
d
ND, not determined.
e
Determined in triplicate via method A. For the MBC determination, statistical evaluation was carried out via one-way ANOVA multiple-comparison test, as for Fig. 1.