TABLE 5.
FICI values for combinations of MMV688845 with antimycobacterial drugs against M. abscessus ATCC 19977a
| Drugb | 7H9 |
MHII |
THP-1 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Conc. (μM) | Conc. of MMV688845 (μM) | FICI | Conc. (μM) | Conc. of MMV688845 (μM) | FICI | Conc. (μM) | Conc. of MMV688845 (μM) | FICI | |
| AMK | 0.8 | 1.6 | 0.7 | 1.3 | 6.3 | 1.2 | — | — | — |
| BDQ | 0.3 | 1.6 | 0.8 | 0.2 | 6.3 | 0.7 | 0.1 | 3.1 | 0.6 |
| CEF | 25 | 1.6 | 0.8 | 12.5 | 1.6 | 0.9 | — | — | — |
| CLR | 0.02 | 3.1 | 0.3 | 0.04 | 3.1 | 0.5 | 3.1 | 1.6 | 0.2 |
| AZM | 0.8 | 3.1 | 0.6 | 1.6 | 1.6 | 0.4 | — | — | — |
| TLM | 0.2 | 3.1 | 0.5 | 0.8 | 3.1 | 0.6 | — | — | — |
| EMB | 50 | 1.6 | 0.9 | — | — | — | — | — | — |
| RFB | 0.3 | 6.3 | 0.7 | 1.6 | 3.1 | 0.9 | 5.0 | 0.8 | 1.0 |
| RMP | 7.8 | 0.8 | 0.6 | 4.7 | 3.1 | 0.5 | — | — | — |
| TEI | 3.1 | 1.6 | 0.4 | 1.6 | 6.3 | 0.9 | — | — | — |
| TIG | 0.1 | 6.3 | 0.7 | 0.8 | 0.4 | 0.5 | 3.1 | 0.8 | 0.6 |
a
All concentrations were determined by RFP signal. —, not determined.
b
AMK, amikacin; AZM, azithromycin; BDQ, bedaquiline; CEF, cefoxitin; CLR, clarithromycin; EMB, ethambutol; RFB, rifabutin; RMP, rifampicin; TEI, teicoplanin; TIG, tigecycline; TLM, telithromycin.