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. 2022 Dec 7;12:990398. doi: 10.3389/fonc.2022.990398

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Copyright © 2022 Obr, Bulatowicz, Chang, Ciliento, Lemenze, Maingrette, Shang, Gallagher, LeRoith and Wood

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered cadherin expression in tumors with reduced IGF1R. (A–I) Representative images of E-cadherin (green) or P-cadherin (red) immunostaining in Wnt1 (A, D, G), DN-Wnt1 (B, E, H), and K8iKOR-Wnt1 (C, F, I) primary tumors. (J) E-cadherin, P-cadherin, and double positive cell count graphs of primary tumors. Statistic: One-Way ANOVA with Tukey’s Multiple Comparison post-hoc test. K. Adhesion (delta cell index) over time in Wnt1 or DN-Wnt1 primary tumors with empty vector (EV) or E-cadherin overexpression (Ecad). n = 3; Statistic: Non-linear regression. (L) Adhesion (delta cell index) over time in Wnt1 or DN-Wnt1 with P-cadherin knockdown (Pcad KD). n = 3; Statistic: Non-linear regression.