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. Author manuscript; available in PMC: 2022 Dec 21.
Published in final edited form as: Cell Rep. 2022 Nov 22;41(8):111709. doi: 10.1016/j.celrep.2022.111709

Figure 5. Ablation of Col1α1+ fibroblasts increases tight junction disruption.

Figure 5.

(A) Representative images of ZO-1 (green) and CD31 (red) in the peri-hematoma region in control and FKO brains in the sham group and at days 2 and 7 after ICH. Scale bars, 50 μm.

(B) Quantification of ZO-1 intensity in the peri-hematoma region in control and FKO brains. n = 4 mice, *p = 0.0286 by Mann-Whitney U test.

(C) Representative images of occludin (green) and CD31 (red) in the peri-hematoma region in control and FKO brains in the sham group and at days 2 and 7 after ICH. Scale bars, 50 μm.

(D) Quantification of occludin intensity in the peri-hematoma region in control and FKO brains. n = 4 mice, *p = 0.0286 by Mann-Whitney U test.

(E) Representative transmission electron microscopy images showing the ultrastructure of endothelial tight junctions in control and FKO brains at day 7 after ICH. Red arrows indicate tight junctions. Scale bars, 400 nm.

Data were shown as mean ± SD.