TABLE 2.

Relationship between point mutations of the erm(41) and rrl genes and clarithromycin susceptibility in Mycobacterium abscessus species

Mutation (n)	Clarithromycin MIC (μg/mL) ata:
	IRT			LRT
	MIC50	MIC90	MIC range	MIC50	MIC90	MIC range
erm(41)
Nonsense mutation C199Tb (1)			0.12			0.12
Missense mutations
T28Cc (11)	0.25	0.25	0.12 to 0.5	2	4	0.12 to 4
G76Ad (1)			4			>16
G158Ae (1)			0.25			0.5
A238Gf (21)	0.25	4	0.06 to 4	4	>16	0.12 to >16
C419Tg (2)	3	4	2 to 4	>16	>16	>16 to >16
Silent mutations
A120Gh (2)	2.25	4	0.5 to 4	>16	>16	>16 to >16
T159Ci (23)	0.25	4	0.06 to 4	4	>16	0.12 to >16
G168Cj (2)	0.625	1	0.25 to 1	>16	>16	0.5 to >16
G255Ak (10)	3	4	0.06 to 4	>16	>16	>16 to >16
G279Tl (9)	2	4	0.06 to 4	>16	>16	>16 to >16
A330Cm (22)	0.375	4	0.06 to 4	>16	>16	0.12 to >16
T336Cn (9)	2	4	0.06 to 4	>16	>16	>16 to >16
rrl mutation A2059Go (1)			>16			>16

^aIRT, initial reading time; LRT, late reading time.

^bMIS128.

^cMIS003, MIS034, MIS122, MIS124, MIS181, MIS194, MIS205, MIS300, MIS314, MIS317, and MIS354.

^dMIS114.

^eMIS219.

^fMIS003, MIS005, MIS034, MIS114, MIS122, MIS124, MIS166, MIS181, MIS194, MIS205, MIS261, MIS283, MIS300, MIS311, MIS314, MIS317, MIS318, MIS324, MIS328, MIS334, and MIS354.

^gMIS114 and MIS339.

^hMIS166 and MIS283.

ⁱMIS003, MIS005, MIS034, MIS114, MIS122, MIS124, MIS128, MIS166, MIS181, MIS194, MIS205, MIS261, MIS283, MIS300, MIS311, MIS314, MIS317, MIS318, MIS324, MIS328, MIS334, MIS339, and MIS354.

^jMIS219 and MIS303.

^kMIS005, MIS114, MIS166, MIS261, MIS283, MIS311, MIS318, MIS324, MIS328, and MIS334.

^lMIS005, MIS114, MIS166, MIS261, MIS283, MIS311, MIS318, MIS324, and MIS328.

^mMIS003, MIS005, MIS034, MIS114, MIS122, MIS124, MIS166, MIS181, MIS194, MIS205, MIS261, MIS283, MIS300, MIS311, MIS314, MIS317, MIS318, MIS324, MIS328, MIS334, MIS339, and MIS354.

ⁿMIS005, MIS114, MIS166, MIS261, MIS283, MIS311, MIS318, MIS324, MIS328.

^oMIS127.