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. 2022 Nov 9;131(12):952–961. doi: 10.1161/CIRCRESAHA.122.321631

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© 2022 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 5. — Schematic representation of the potential role for neuronal nitric oxide synthase in neurovascular coupling in humans. A, B, structure of the neurovascular unit. C, rise in regional cerebrovascular blood flow following stimulation consists of a rapid initial phase followed by a sustained phase. Neuronal activation initiates downstream cascades that promote NO production via nNOS, which affects the rapid initial phase of response. The sustained phase may be more dependent on eicosanoids (EN) and potassium (K+). Nitric oxide (NO), neuronal nitric oxide synthase (nNOS), adenosine triphosphate (ATP).