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. 2022 Nov 2;131(12):1004–1017. doi: 10.1161/CIRCRESAHA.122.321146

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© 2022 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Effects of FES (FES proto-oncogene, tyrosine kinase) knockdown, rs17514846, and rs1894401 on monocyte behavior. A and B, Human peripheral blood monocytes transfected with either negative control small interfering RNA (siRNA) or FES siRNA (knockdown of FES is shown in Figure S2A) were subjected to trans-well migration assay (A) and apoptosis assay (following incubation with the apoptosis inducer staurosporine for 4 h; B), respectively. Columns and error bars represent mean±SD; P values are from 2-tailed Wilcoxon matched-pairs signed-rank test. C and D, Results of trans-well migration assays of isogenic monocytic cells of either the rs1894401 C/C or A/A genotype (C) and isogenic monocytic cells of either the rs1894401 A/A or G/G genotype (D). Columns and error bars represent mean±SD; P values from Kruskal-Wallis test with multiple comparisons adjusting for the number of comparison.