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. 2022 Nov 2;131(12):1004–1017. doi: 10.1161/CIRCRESAHA.122.321146

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© 2022 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 8. — Differences between Fes^-/-/Apoe^-/- mice and Fes^+/+/Apoe^-/- mice in atherosclerotic lesion size and composition. Fes^-/-/Apoe^-/- mice and Fes^+/+/Apoe^-/- littermates were fed a high fat diet for 12 weeks from 6 weeks of age. Thereafter, aortic root sections were subjected to hematoxylin/eosin staining (A), immunostaining for monocytes/macrophages (MOMA2) (B), immunostaining for smooth muscle cells (SMA) (C), and Masson trichrome staining for collagen (D). Morphometric quantification was performed with the use of Fiji software. Arrows indicate stain-positive areas. Bars, 200 μm. Mean (SD) values in the Fes^-/-/Apoe^-/- group and the Fes^+/+/Apoe^-/- group, respectively, were 0.505 (0.067) mm² and 0.365 (0.111) mm² for atherosclerotic lesion area in the aortic root sections (A), 44.52% (7.97%) and 34.02% (9.25%) for MOMA2 positive stain area (B), 19.36% (5.32%) and 14.73% (2.57%) for SMA positive stain area (C), and 1.97% (1.45%) and 4.16% (2.06%) for collagen positive stain area (D). Numbers per group are shown in the figure. P values are from 2-tailed Mann-Whitney test.