Table 3. Risk of ICU admission among solid organ transplant recipients diagnosed with COVID-19.
| Univariable | Multivariable | |||
|---|---|---|---|---|
| Logistic regression model | (N = 646) | (N = 626) | ||
| Event: ICU admission, n = 136 | OR (95% CI) | p-value | OR (95% CI) | p-value |
| Age at encounter (years) | 1.01 (1.00, 1.03) | 0.051 | -- | -- |
| Gender | ||||
| Female | (reference) | -- | -- | |
| Male | 1.11 (0.76, 1.63) | 0.58 | -- | -- |
| Race/Ethnicity | ||||
| NH White | (reference) | -- | -- | |
| NH Black | 1.13 (0.70, 1.81) | 0.62 | -- | -- |
| NH Asian | 0.41 (0.12, 1.39) | 0.15 | -- | -- |
| NH Other Race | 0.36 (0.05, 2.91) | 0.34 | -- | -- |
| Hispanic or Latino | 0.95 (0.60, 1.51) | 0.84 | -- | -- |
| Body Mass Index | 1.02 (0.99, 1.05) | 0.27 | 1.02 (0.99, 1.05) | 0.18 |
| Charlson Comorbidity Index Score | 1.08 (1.04, 1.13) | <0.001 | 1.09 (1.04, 1.15) | <0.001 |
| Transplanted organ | ||||
| Multi-organ | 1.38 (0.48, 3.95) | 0.55 | 1.34 (0.44, 4.10) | 0.61 |
| Heart | 0.73 (0.35, 1.50) | 0.39 | 0.53 (0.25, 1.12) | 0.1 |
| Kidney | (reference) | (reference) | ||
| Liver | 1.10 (0.66, 1.86) | 0.71 | 0.72 (0.40, 1.29) | 0.27 |
| Lung | 1.44 (0.80, 2.59) | 0.22 | 1.16 (0.62, 2.16) | 0.64 |
| Kidney/Pancreas | 0.74 (0.28, 2.00) | 0.56 | 0.76 (0.28, 2.10) | 0.6 |
| Time from transplant to COVID-19 diagnosis (years) | 1.00 (0.97, 1.04) | 0.85 | ||
| Vaccination status | ||||
| Unvaccinated, diagnosed in 2020 | 1.29 (0.84, 1.99) | 0.24 | 1.30 (0.84, 2.01) | 0.25 |
| Unvaccinated, diagnosed in 2021 | (reference) | (reference) | ||
| Diagnosed <180 days after vaccination | 0.49 (0.23, 1.02) | 0.06 | 0.45 (0.21, 0.95) | 0.04 |
| Diagnosed 180+ days after vaccination | 0.83 (0.38, 1.84) | 0.65 | 0.68 (0.30, 1.53) | 0.35 |
Model notes: Includes all SOT recipients receiving immunosuppressant treatments at time of COVID-19 diagnosis. Outcome: ICU admission within 30 days of COVID-19 diagnosis; OR, odds ratio; CI: Confidence interval; ICU: Intensive care unit.