Table 3. Factors associated with the progression of microbleeds.

	Unadjusted HR (95% CI*)	P-value
PPI use	1.368 (0.321–5.831)	0.672
Never use	1 (References)
Intermediate use	1.603 (0.176–14.637)	0.676
Long term use	3.473 (0.381–31.673)	0.270
Age at initial imaging	0.952 (0.872–1.038)	0.265
Hypertension	1.666 (0.397–6.983)	0.581
Diabetes	2.836 (0.018–45.283)	0.371
Dyslipidemia	0.804 (0.161–4.005)	0.804
Previous stroke/TIA	1.777 (0.356–8.867)	0.910
Coronary heart disease	1.128 (0.138–9.190)	0.910
Use of antiplatelet agents	1.430 (0.285–7.179)	0.664

*Abbreviation: HR, hazard ratio; CI, confidence interval; PPI, proton pump inhibitor; MRI, magnetic resonance imaging; TIA, transient ischemia attack