FIG. 5.

Effect of H. pylori products on cell proliferation. (Top panels) PBMCs (left) or Jurkat T cells (right) cultured with H. pylori products alone. (Bottom panels) PBMCs (left) or Jurkat T cells (right) cultured with H. pylori products and PHA plus PMA. Cell cultures were performed as described in the legend to Fig. 2. After an incubation period of 24 h, tritiated thymidine incorporation was determined after an additional 12 h. Values are mean cpm ± standard errors. Due to variation in baseline proliferation of Jurkat T cells, values were normalized to 100% for these cells. # and ##, significant increase (#, P < 0.05; ##, P < 0.01). ∗ and ∗∗, significant decrease (∗, P < 0.05; ∗∗, P < 0.01). The top row of symbols refers to urease values, the middle row refers to lysate, and the bottom row refers to intact bacteria.