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. 2022 Dec 16;101(50):e31598. doi: 10.1097/MD.0000000000031598

Table 4.

Correlation of PADI4 and interleukin 33 (IL-33) polymorphisms with nephritis in juvenile systemic lupus erythematosus (JSLE) patients.

Genes SNPs Genotype Without nephritis, n (%) With nephritis, n (%) Age- and gender-adjusted OR (95% CI)a P a
PADI4 rs2240337 TT + CT 9 (11.2) 13 (20.3) 1.00 (ref.)
CC 71 (88.8) 51 (79.7) 0.47 (0.19–1.19) .11
PADI4 rs2240340 TT + CT 53 (66.2) 47 (73.4) 1.00 (ref.)
CC 27 (33.8) 17 (26.6) 0.69 (0.33–1.42) .31
IL-33 rs1891385 AA + CA 74 (92.5) 56 (87.5) 1.00 (ref.)
CC 6 (7.5) 8 (12.5) 1.72 (0.56–5.27) .35
IL-33 rs1929992 CC + CT 55 (68.8) 54 (84.4) 1.00 (ref.)
TT 25 (31.2) 10 (15.6) 0.42 (0.180.96) .041

Bold values are statistically significant (P < .05).

CI = confidence interval, IL-33 = interleukin 33, PADI4 = peptidyl arginine deiminase type IV, OR = odds ratio.

a

Logistic regression models were used to calculate odds ratios (ORs) and 95% CIs.