Table 4.
Genes | SNPs | Genotype | Without nephritis, n (%) | With nephritis, n (%) | Age- and gender-adjusted OR (95% CI)a | P a |
---|---|---|---|---|---|---|
PADI4 | rs2240337 | TT + CT | 9 (11.2) | 13 (20.3) | 1.00 (ref.) | |
CC | 71 (88.8) | 51 (79.7) | 0.47 (0.19–1.19) | .11 | ||
PADI4 | rs2240340 | TT + CT | 53 (66.2) | 47 (73.4) | 1.00 (ref.) | |
CC | 27 (33.8) | 17 (26.6) | 0.69 (0.33–1.42) | .31 | ||
IL-33 | rs1891385 | AA + CA | 74 (92.5) | 56 (87.5) | 1.00 (ref.) | |
CC | 6 (7.5) | 8 (12.5) | 1.72 (0.56–5.27) | .35 | ||
IL-33 | rs1929992 | CC + CT | 55 (68.8) | 54 (84.4) | 1.00 (ref.) | |
TT | 25 (31.2) | 10 (15.6) | 0.42 (0.18–0.96) | .041 |
Bold values are statistically significant (P < .05).
CI = confidence interval, IL-33 = interleukin 33, PADI4 = peptidyl arginine deiminase type IV, OR = odds ratio.
Logistic regression models were used to calculate odds ratios (ORs) and 95% CIs.