Table 3.
Adverse events of patients with advanced hepatocellular carcinoma who underwent chemotherapy.
| No. of patients with CTCAE Grade 3/4 (n) | ||
| Adverse event | FOLFOX4 | ATRA + FOLFOX |
| Headache | – | – |
| Fatigue | 2 | 3 |
| Nausea | 4 | 4 |
| Diarrhea | – | – |
| Thrombocytopenia | – | – |
| Leukocytopenia | 11 | 11 |
| ALT increase | 1 | 1 |
| Bilirubin increase | 1 | 1 |
| ALP increase | 0 | 1 |
| Hypoalbuminemia | – | – |
ATRA: All-trans-retinoic acid; CTCAE: Common Terminology Criteria for Adverse Events; FOLFOX4: Infusional fluorouracil, leucovorin, and oxaliplatin; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase.