Table 1.

Regulatory factors of ferroptosis.

Regulatory factors	Possible pathways	References
NRF2, p53, BAP1, BECN1, erastin, RSL3	System xc− –GPX4	[14,18,20–22]
LOXs, ACSL4, NRF2	Lipid peroxidation	[30–32,65]
IRE-BP2, TF, TFR, NCOA4, HO1, PROM2, NRF2	Iron metabolism	[8,23,41,43–46,65]
FSP1	FSP1-CoQ10-NAD(P)H	[48,49]

ACSL4: Long-chain fatty acid–coenzyme A (CoA) ligase 4; BAP1: Breast cancer susceptibility gene 1 (BRCA1) associated protein 1; BECN1: Beclin 1; CoQ10: Coenzyme Q10; FSP1: Ferroptosis suppressor protein 1; GPX4: glutathione peroxidase 4; HO1: Heme oxygenase 1; IRE-BP2: Iron responsive element binding protein 2; LOXs: Lipoxygenases; NAD(P)H: Nicotinamide adenine dinucleotide; NCOA4: Nuclear receptor coactivator 4; NQO1: Quinone oxidoreductase 1; NRF2: Nuclear factor erythroid 2-related factor; PROM2: Prominin-2; RSL3: RAS-selective lethal 3; TF: Transferrin; TFR: Transferrin receptor.