Table 9.

Secondary outcomes.

Outcomes	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Quality of evidence
HR	Serious*	No serious	No serious	Serious†	None	⊕⊕◯◯ LOW
VO2max	Serious*	No serious	No serious	Serious†	None	⊕⊕◯◯ LOW
FMD	Serious*	No serious	No serious	Serious†	None	⊕⊕◯◯ LOW

GRADE Working Group grades of evidence.

High certainty: We are very confident that the true effect lies close to that of the estimate of the effect.

Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.

Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect.

Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.

FMD = flow-mediated vasodilation, SBP = systolic blood pressure, VO2max = maximum oxygen uptake.

^*Incomplete outcome data.

^†The sample size is small.