Table 2.

Docking scores determined using SystemsDock for the binding interactions between Asperosaponin VI (ASA VI), its endogenous ligands, and the predicted target proteins.

No.	Target protein name	Endogenous ligand docking score	ASA VI docking score	Signal pathways of the target protein
1	MAP3K3	3.88	8.342	MAPK signaling pathway Neurotrophin signaling pathway
2	ESR2	5.01	8.134	Oestrogen signaling pathway
3	IGF1R	4.09	8.092	MAPK signaling pathway AMPK signaling pathway FoxO signaling pathway PI3K-AKT signaling pathway
4	RAC1	4.1	8.006	Neurotrophin signaling pathway PI3K-AKT signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway
5	PTPRE	5.01	7.997	Insulin signaling pathway
6	CAMK4	4.25	7.934	Neurotrophin signaling pathway
7	KDR	5.86	7.905	MAPK signaling pathway PI3K-AKT signaling pathway
8	MMP14	7.59	7.839	GnRH signaling pathway
9	LYN	3.62	7.835	Chemokine signaling pathway
10	HCK	4.5	6.464	Chemokine signaling pathway
11	ERBB4	4.64	5.06	MAPK signaling pathway PI3K-AKT signaling pathway
12	MMP2	4.83	4.881	Oestrogen signaling pathway
13	THBS1	5.25	4.639	PI3K-AKT signaling pathway
14	THRB	6.12	4.387	Thyroid signaling pathway
15	HBEGF	4.67	4.139	Neurotrophin signaling pathway

ASA VI = Asperosaponin VI, CAMK4 = calcium-dependent protein kinase IV, ERBB4 = epidermal growth factor receptor, ESR2 = estrogen receptor 2, GnRH = , HBEGF = proheparin-binding EGF-like growth factor, HCK = HCK proto-oncogene, IGF1R = insulin like growth factor 1 receptor, KDR = kinase insert domain receptor, LYN = tyrosine-protein kinase Lyn, MAP3K3 = mitogen-activated protein kinase 3, MMP2 = matrix metalloproteinases-2, MMP14 = matrix metalloproteinases-14, PTPRE = protein-tyrosine phosphatase epsilon, RAC1 = Ras-related C3 botulinum toxin substrate 1, THBS1 = thrombospondin 1, THRB = thyroid hormone receptor beta.