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. 2022 Dec 21;11(2):e207–e217. doi: 10.1016/S2214-109X(22)00520-4

Table 2.

COVID-19 vaccine indicators by education level: median national prevalence, disaggregated estimates, and crude and adjusted SII, globally and by country income group

Number of countries Median national prevalence (95% CI) Median disaggregated data (95% CI)
Median SII, percentage points (95% CI)
No or primary education Secondary education Higher education Unadjusted Adjusted Adjusted2
Self-reported receipt of COVID-19 vaccine
Global 90 75·2% (72·1–79·8) 67·7% (60·0–73·0) 71·4% (67·4–76·1) 79·1% (75·6–82·4) 16·4 (13·4 to 19·3) 11·3 (9·1 to 12·7) 11·9 (10·2 to 13·4)
High-income countries 33 86·0% (81·6–87·5) 81·0% (78·3–87·1) 83·8% (78·8–86·0) 87·4% (83·4–89·0) 10·3 (7·3 to 12·2) 6·9 (5·6 to 8·7) 6·9 (6·0 to 8·3)
Upper-middle-income countries 29 71·5% (65·6–77·9) 57·6% (52·5–72·3) 66·7% (58·8–73·9) 75·5% (68·1–82·1) 21·4 (17·3 to 24·5) 14·3 (11·9 to 16·7) 14·5 (12·9 to 17·1)
Low-income and lower-middle-income countries 28 58·1% (51·0–73·0) 50·7% (41·8–59·6) 51·2% (41·9–67·0) 63·9% (53·0–75·6) 19·5 (14·2 to 26·6) 13·9 (9·3 to 16·8) 13·3 (11·1 to 18·1)
Experienced structural barrier to vaccination
Global 90 23·9% (20·4–27·4) 25·3% (21·8–28·5) 23·6% (19·6–26·6) 23·1% (20·2–25·7) −3·7 (−6·4 to −1·5) 3·8 (2·6 to 4·7) 3·6 (2·4 to 5·4)
High-income countries 33 15·0% (14·1–17·1) 12·6% (11·6–14·0) 13·5% (12·5–15·1) 16·9% (15·4–19·8) 2·2 (0·2 to 4·8) 4·8 (3·6 to 8·6) 5·3 (3·4 to 9·0)
Upper-middle-income countries 29 24·0% (21·5–29·9) 27·0% (22·5–31·2) 23·6% (21·3–30·0) 23·4% (21·5–27·3) −5·5 (−8·5 to −3·5) 3·7 (2·0 to 7·5) 3·1 (1·2 to 6·3)
Low-income and lower-middle-income countries 28 34·6% (29·3–38·9) 38·3% (32·9–45·5) 33·5% (28·3–40·5) 34·1% (28·3–38·1) −8·3 (−11·0 to −6·5) 0·5 (−1·3 to 4·6) 1·1 (−1·4 to 6·6)
Vaccine hesitancy (unvaccinated people)
Global 90 39·9% (37·0–41·7) 38·7% (37·3–40·1) 41·1% (39·0–43·0) 38·2% (35·7–41·7) −4·1 (−6·0 to −1·0) −4·6 (−7·0 to −3·3) −3·8 (−6·4 to −1·4)
High-income countries 33 34·9% (33·7–37·7) 38·8% (35·5–41·4) 39·1% (34·8–42·4) 33·1% (31·4–36·2) −7·0 (−8·2 to −2·8) −6·7 (−9·5 to −4·0) −6·4 (−10·5 to −2·3)
Upper-middle-income countries 29 41·7% (37·7–44·8) 39·2% (37·1–41·2) 43·5% (40·3–45·2) 40·7% (34·7–44·6) −5·7 (−9·6 to 0·6) −4·9 (−9·6 to −1·8) −4·9 (−8·6 to −0·2)
Low-income and lower-middle-income countries 28 41·4% (39·2–46·5) 37·8% (32·5–41·6) 40·9% (38·3–44·0) 44·0% (40·2–46·8) 1·2 (−2·8 to 7·0) 2·1 (−4·4 to 5·3) 1·8 (−4·5 to 7·5)
Vaccine refusal (unvaccinated people)
Global 90 28·8% (24·5–37·2) 27·4% (23·8–38·0) 26·7% (20·0–36·3) 28·3% (24·3–37·6) 6·0 (4·4 to 8·0) 4·0 (2·5 to 6·3) 2·5 (1·4 to 4·8)
High-income countries 33 47·4% (39·0–59·1) 42·8% (31·2–49·0) 46·9% (37·0–57·4) 50·7% (40·5–60·7) 8·5 (6·0 to 12·4) 9·6 (5·7 to 10·7) 8·1 (3·1 to 10·1)
Upper-middle-income countries 29 27·3% (22·5–33·6) 24·9% (17·4–35·0) 24·3% (14·1–34·7) 27·7% (21·5–34·2) 6·0 (3·2 to 10·7) 2·9 (−0·0 to 7·3) 1·5 (−0·1 to 5·7)
Low-income and lower-middle-income countries 28 18·5% (15·1–24·2) 19·5% (16·1–24·7) 17·3% (12·9–21·9) 17·5% (14·8–24·2) 2·2 (−0·9 to 5·0) 1·0 (−1·6 to 3·1) −0·3 (−2·0 to 1·9)

Medians are based on countries with sample sizes of at least 100 in each education subgroup. Disaggregated data estimates excluded countries with insufficient sample size; estimates based on 87 countries for experienced structural barrier (28 upper-middle-income countries and 26 low-income and lower-middle-income countries) and 86 countries for vaccine hesitancy and vaccine refusal (31 high-income and 26 low-income and lower-middle-income countries). SII of 0 indicates no inequality; SII above 0 denotes higher indicator prevalence among people with more education, and SII below 0 denotes higher indicator prevalence among people with less education. The first adjusted model (adjusted) controlled for individual sociodemographic characteristics (age, gender, place of residence, and household overcrowding). The second adjusted model (adjusted2) controlled for these characteristics plus the presence of health risk factors and COVID-19-like symptoms. SII=slope index of inequality.