Table 3.
Cardiomyocyte size and nuclearity.
| Fetal control (n = 7) | Preterm SAL (n = 9) | Preterm LPS (n = 9) | |
|---|---|---|---|
| LV + S | |||
| Cross-sectional area (µm2) | 39.6 ± 2.2 | 49.5 ± 4.1* | 56.5 ± 8.5* |
| Mononucleated (%) | 44.9 ± 1.5 | 31.7 ± 2.4* | 31.8 ± 1.3* |
| Binucleated (%) | 55.0 ± 1.5 | 68.2 ± 2.4* | 68.0 ± 1.5* |
| Multinucleated (>2 nuclei) (%) | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.2 ± 0.4 |
| RV | |||
| Cross-sectional area (µm2) | 61.0 ± 3.5 | 53.3 ± 6.4* | 52.8 ± 5.6* |
| Mononucleated (%) | 38.0 ± 1.9 | 31.0 ± 1.0* | 32.0 ± 1.0* |
| Binucleated (%) | 61.9 ± 1.9 | 68.4 ± 1.1* | 67.7 ± 0.7* |
| Multinucleated (>2 nuclei) (%) | 0.1 ± 0.1 | 0.6 ± 0.6 | 0.3 ± 0.5 |
Cardiomyocyte size (cross-sectional area) and nuclearity from the left ventricle + septum (LV + S) and right ventricle (RV). Statistical analyses were performed using a one-way ANOVA followed by a Bonferroni post hoc test. Data presented as mean ± SD. Significance accepted at p < 0.05: *significant difference compared to fetal control.