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. 2022 Dec 7;612(7941):720–724. doi: 10.1038/s41586-022-05477-4

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Black horizontal line corresponds to P = 5 × 10⁻⁹, the GWAS significance threshold used for all analyses. Note that some y-axis scales are discontinuous to better illustrate variants with very small P-values (e.g., the Drinks per Week y-axis is cut at 30 with a maximum value of 307.7, denoting a P-value of 1.9 × 10⁻³⁰⁸). All P-values are from two-sided statistical tests.