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. 2022 Dec 19;4(12):1812–1829. doi: 10.1038/s42255-022-00681-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — A.- Quantification of percentage splice in (PSI) for Pla2g6 (exon 10), (B.-) Scarb1 (exon 12), (C.-) Numb (exon 3), (D.-) Numb (exon 9), (E.-) Sec31a (exon 23) and (F.-) Osbpl9 (exon 6) in L^WT and L^ΔRbfox2 mice fed a CD, a HFD or a HFr diet (n = 7-10). G.- Representative western-blot showing RBFOX2 expression levels in the liver of mice after transduction with pAd-RBFOX2 or pAd-GFP control (left) and quantification by PCR/capillary electrophoresis of percentage splice in (PSI) for Scarb1 (exon 12) (right) (n = 7-9). H.-ChIP-seq signal for FOXA1 in mouse Rbfox2 promoter in liver. I.- Volcano-plot showing LC-MS lipidomic analysis of L^ΔRbfox2 vs L^WT hepatocytes normalised to internal standard and total cell counts (n = 5-6). J.- PCA plot of L^ΔRbfox2 vs. L^WT hepatocytes and relevant SSO treatment as determined by LC-MS lipidomic analysis. Results are represented as mean ± s.e.m. Statistical significance was determined by two-way ANOVA with Tukey’s multiple comparisons test (A-F) or two-tailed unpaired t-test (G) of biologically independent samples.

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