Table 1.

Demographic and characterizing data of the CerebNet data set cohort consisting of pre-ataxic and ataxic SCA3 mutation carriers as well as healthy controls (HC). ¹Time to onset is given in years. The reported time from onset (defined as the first occurrence of gait disturbances) is given where available and for the remaining seven pre-ataxic mutation carriers, not yet experiencing gait disturbances, we estimated the time to onset following the model introduced by Tezenas et al. [42], which depends on both the number of CAG RL as well as the actual age; SD = standard deviation, CAG RL = CAG repeat length of the longer allele.

Group	N	age [years]	sex	SARA	Time to ataxia onset1	CAG RL
		mean $\pm$ SD [range]	m/f	mean $\pm$ SD [range]	mean $\pm$ SD [range]	mean $\pm$ SD
HC	10	43.9 $\pm$ 13.22 [22; 63]	4/6	0.3 $\pm$ 0.54 [0; 1.5]	n.a.	n.a.
pre-ataxic SCA3	11	31.6 $\pm$ 7.1 [20; 43]	4/7	1.4 $\pm$ 0.8 [0; 2.5]	-4.5 $\pm$ 6.4 [-13.8; 8.0]	72.4 $\pm$ 3.1
ataxic SCA3	9	44.6 $\pm$ 7.3 [32; 57]	6/3	12.6 $\pm$ 4.5 [7; 19]	8.4 $\pm$ 5.4 [1.0; 8.0]	70.89 $\pm$ 4.11