. 2022 Oct 31;20:121–128. doi: 10.1016/j.ijpddr.2022.10.003

Table 1.

IC₅₀ inhibition data of CQ and acetylenic compounds against P. falciparum strains according to the growth inhibition assay.

Compounds	Growth Inhibition Assay	P. falciparum IC₅₀ (nM)
Compounds	Growth Inhibition Assay	3D7	Dd2	IPC 4912	RF12
DAQ	SYBR green I	43 ± 5	51 ± 2	49 ± 3	NT
DAQ	LDH	53 ± 9	68 ± 1	NT	79 ± 10
DAQ_M	SYBR green I	34 ± 4	61 ± 8	NT	NT
DAQ_M	LDH	23 ± 2	91 ± 9	NT	86 ± 11
CQ	SYBR green I	15 ± 2	2313 ± 475	139 ± 5	NT
CQ	LDH	21 ± 1	211 ± 16	NT	205 ± 6

NT: Not tested. The SYBR green I growth inhibition assay was performed in triplicates for DAQ, DAQ_M and CQ. The LDH growth inhibition assay for DAQ and DAQ_M was performed in duplicates. CQ was tested 8 times against the 3D7 strain using the LDH assay, and in duplicates against the Dd2 and RF12 strains. Individual IC₅₀ values are reported in Table S1.