Table 1.
Baseline demographic and clinical characteristics of patients with renal underexcretion–type gout receiving either LDBen or LDFeb*
| LDBen (n = 98) | LDFeb (n = 98) | |
|---|---|---|
| Demographic and clinical characteristics | ||
| Age, mean ± SD years | 43.89 ± 13.10 | 43.29 ± 12.22 |
| Male, no. (%) of patients | 98 (100) | 98 (100) |
| Height, mean ± SD cm | 174.01 ± 5.84 | 175.37 ± 5.73 |
| Body weight, mean ± SD kg | 81.07 ± 9.82 | 82.98 ± 11.27 |
| Body mass index, mean ± SD kg/m2 | 26.77 ± 2.85 | 26.97 ± 3.21 |
| SBP, mean ± SD mm Hg | 133.19 ± 16.23 | 134.18 ± 15.32 |
| DBP, mean ± SD mm Hg | 84.21 ± 10.80 | 85.84 ± 12.09 |
| Gout feature | ||
| Serum urate, median (IQR) mg/dl | 8.70 (7.91–9.06) | 8.77 (8.10–9.27) |
| Age at onset, mean ± SD years | 39 ± 12 | 38 ± 10 |
| Duration of gout, mean ± SD years | 5.2 ± 4.6 | 5.6 ± 4.8 |
| Gout flare frequency, no. (%) of patients | ||
| Less than twice a year | 48 (49) | 45 (46) |
| Twice or more than twice a year | 50 (51) | 53 (54) |
| Tophus, no. (%) of patients | 18 (18) | 18 (18) |
| Family history of gout, no. (%) of patients | 16 (16) | 21 (21) |
| ULT naive, no. (%) of patients | 75 (77) | 79 (81) |
| Coexisting conditions, no. (%) of patients | ||
| Obesity | 40 (41) | 32 (33) |
| Hypertension | 16 (16) | 20 (20) |
| Cardiovascular disease | 2 (2) | 0 (0) |
| Fatty liver | 17 (17) | 24 (24) |
| Hyperlipidemia | 20 (20) | 17 (17) |
| Diabetes | 15 (15) | 14 (14) |
| Blood chemistry parameters | ||
| Serum creatinine, median (IQR) μmoles/liter | 82 (76–93) | 85 (76–95) |
| Fasting glucose, mean ± SD mmoles/liter | 5.52 ± 0.68 | 5.56 ± 0.63 |
| Cholesterol, mean ± SD mmoles/liter | 4.84 ± 0.82 | 4.76 ± 1.17 |
| Triglyceride, median (IQR) mmoles/liter | 1.69 (1.17–2.34) | 1.67 (1.25–2.53) |
| AST, median (IQR) units/liter | 21.00 (18.00–24.25) | 19 (17–24) |
| ALT, median (IQR) units/liter | 26.0 (18.0–37.5) | 23.50 (16.75, 36.00) |
| eGFR, mean ± SD ml/minute/1.73 m2 | 96.30 ± 15.51 | 94.60 ± 15.09 |
*
LDBen = low‐dose benzbromarone; LDFeb = low‐dose febuxostat; SBP = systolic blood pressure; DBP = diastolic blood pressure; IQR = interquartile range; ULT = urate‐lowering therapy; AST = aspartate aminotransferase; ALT = alanine aminotransferase; eGFR = estimated glomerular filtration rate.