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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Arthritis Rheumatol. 2022 Oct 31;74(12):2003–2014. doi: 10.1002/art.42286

Figure 4.

Figure 4.

Regulons and Transcription Factors predicted to be important for SPP1 Mφ during analysis of macrophages, dendritic cells, proliferating Mφ from 5 lung samples in scRNA-seq 3’ v3 chemistry by SCENIC. (A) Cell clusters are identified as follows: 0- SSc-ILD FABP4 Mφ (blue), 1- SSc-ILD SPP1 Mφ (green), 2- HC SPP1 and FABP4 Mφ (purple), 3- SSc-ILD and HC FCN1 Mφ (pink), 4- Proliferating Mφ (yellow), 5- Dendritic cells (light blue). (B) SPP1 is a target gene for ATF5 and TFEB transcription factors and regulons. (C) Transcription factor DotPlot predicted to be important for SPP1 Mφ by SCENIC including transcription factors ATF5 and TFEB indicated in red box. (D) Regulon DotPlot predicted to be important for SPP1 Mφ by SCENIC including regulons ATF5 and TFEB indicated in red box.