Table 3.
Multivariable analysis of predictors of short-term (1-year) post-transplant mortality in TAH-t bridge-to-transplant patients
| Variables | Adjusted Hazard Ratio |
95% Hazard Ratio Confidence Limits |
P value | |
|---|---|---|---|---|
| Recipient BMI (per 1 kg/m2 increase) | 1.06 | 1.02 | 1.11 | 0.003 |
| Ischemic cardiomyopathy | 2.17 | 1.42 | 3.32 | <0.001 |
| Pre-transplant mechanical ventilation | 7.10 | 2.96 | 17.3 | <0.001 |
| Creatinine (per 1 mg/dL increase) | 1.46 | 1.28 | 1.66 | <0.001 |
| Total bilirubin (per 1 mg/dL increase) | 1.16 | 1.10 | 1.23 | <0.001 |
| Donor recipient gender mismatch | 2.20 | 1.27 | 3.79 | 0.004 |
| Simultaneous heart-kidney transplant | 0.37 | 0.14 | 0.94 | 0.04 |
| Cumulative center volume<20 casesa | 1.74 | 1.07 | 2.84 | 0.03 |
| Duration between TAH-t implant and heart transplant | ||||
| <3 months | Ref | - | - | - |
| 3-6 months | 1.11 | 0.59 | 2.07 | 0.75 |
| >6 months | 1.16 | 0.55 | 2.44 | 0.70 |
| TAH-t implantation era | ||||
| 2010-2015 | Ref | - | - | - |
| 2016-2020 | 0.72 | 0.43 | 1.21 | 0.21 |
BMI: Body Mass Index; TAH-t: Total Artificial Heart
a
Cumulative center volume refers to the total volume of heart transplantation among TAH-t bridge to transplantation patients during the study period (2005-2020)